Segmental longitudinal strain and regional myocardial work index could help identify mitral valve prolapse patients with increased risk of ventricular arrhythmia

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Mitral valve prolapse (MVP) could associate with malignant ventricular arrhythmias. annular disjunction (MAD), which leads to excessive mobility, mechanical stretch, and myocardial damage, has been studied as a putative mechanism for an arrhythmic substrate. However, it is unclear whether that the only sufficient risk factor in patients. The aim our study was check two–dimensional speckle tracking echocardiography (STE) segmental longitudinal strain STE-derived work (MW) analysis may allow more accurate assessment MVP Methods results Seventy-two patients twenty healthy volunteers enrolled had performed STE assessment. Non-sustained tachycardia (NSVT) outcome further calculations. Pre-specified cut-off values peak (PSS) index (MWI) basal lateral (−25% 2200 mmHg%), mid-lateral 2500 mid posterior 2400 inferior (−23% mmHg%) segments were predictors NSVT. A combination PSS MWI increased probability NSVT occurrence, reaching highest predictive value segment (Figure): odds ratio 32.15 (3.78–273.8), p < 0.001 ≥ (−25%) mmHg%. Conclusions 2D be valuable tool assessing Excessively augmented regional identifies